Distinguished Scientist, Biologics Discovery

Johnson & Johnson

Lead biologics discovery process as a Distinguished Scientist at Johnson & Johnson. Serve as a strategic leader ensuring end-to-end decision-making on biologics programs with technical expertise.

Posted 7/2/2026full-timeSpring House • Pennsylvania • 🇺🇸 United StatesSeniorLeadWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates deep technical expertise in protein structure, developability principles, and end-to-end biologics development, with a strong ability to lead cross-functional projects and influence decision-making in a matrixed environment.

Highest-signal resume keywords

PhD In Structural BiologyBiopharmaceutical R&D ExperienceProtein Structure ExpertiseEnd-To-End Biologics DevelopmentCross-Functional Project Leadership

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Protein Structure AnalysisDevelopability PrinciplesExpression ConsiderationsCMC Strategy IntegrationRisk Mitigation

Soft Skills

Excellent CommunicationInterpersonal SkillsScientific Storytelling

Tools & Technologies

Predictive ModelingSequence/Structure Analysis ToolsComputational Developability Platforms

Industry Keywords

Therapeutic DiscoveryDiscovery TeamsIND-Enabling DevelopmentPreclinical SciencesTranslational Safety

About the role

Key responsibilities & impact

Serve as the scientific and strategic leader between Therapeutic Discovery & Supply (TDS) and Discovery teams
Enable seamless end‑to‑end decision‑making for biologics programs and technical platforms
Identify and mitigate development risks during the discovery phase
Ensure that structural, biophysical, expression, and developability insights are effectively integrated into CMC strategies and program planning
Identify early opportunities to assess knowledge gaps to derisk program development
Lead platform alignment efforts to ensure data and decisions are translatable across discovery and development
Provide deep scientific guidance on molecule selection, engineering, developability, manufacturability, expression, and protein structure–function considerations
Build trusted cross‑functional partnerships and influencing decision‑making across Therapeutics Discovery (TD), Preclinical Sciences & Translational Safety (PSTS), Therapeutic Areas (TAs), and TDS

Requirements

What you’ll need

PhD in Structural Biology, Biochemistry, Biophysics Chemical or Biomedical Engineering, or a closely related field
A minimum of 15 years of biopharmaceutical R&D experience spanning both Discovery and Development / CMC functions
Deep technical expertise in protein structure, developability principles, and expression considerations
Strong understanding of end‑to‑end biologics development including scientific and operational needs of CMC
Proven ability to shape and implement large cross-functional projects in a matrixed environment
Excellent communication, interpersonal, and scientific storytelling skills.
Experience supporting IND‑enabling or early clinical development efforts preferred
Familiarity with predictive modeling, sequence/structure analysis tools, or computational developability platforms preferred

Benefits

Comp & perks

Inclusive work environment
Health insurance
Flexible work arrangements